Abnormalities in erythrocyte membrane protein in pseudohypoparathyroidism type 1.

The erythrocyte membrane proteins of patients with pseudohypoparathyroidism type 1 and healthy volunteers were analysed by two-dimensional polyacrylamide gel electrophoresis in combination with a sensitive silver staining method. Electrophoretograms from patients were invariably different from control separations with respect to at least three protein spots. The possible relationship with the regulatory component of adenyl cyclase is discussed.