Rapamycin inhibits corneal allograft rejection and neovascularization.

Olsen T W, Benegas N M, Joplin A C, Evangelista T, Mindrup E A, Holland E J

СтатьяПоддержка исследования: вне правительства СШАПеревод пока не подготовлен

Аннотация

OBJECTIVE

To investigate the immunosuppressive effect of rapamycin in prolonging allograft survival in the rat model of orthotopic allogeneic penetrating keratoplasty.

DESIGN

Thirty inbred Lewis rats received corneal allografts from Brown Norway donors. Animals were divided into two rapamycin treatment groups and one allogeneic control group.

RESULTS

By the second week after surgery, all of the control animals had experienced allograft failure due to allograft rejection. However, allografts in seven of 10 animals in the low-dose treatment group and allografts in seven of nine animals in the high-dose treatment group remained clear. In addition, corneal neovascularization was markedly reduced in the treated animals.

CONCLUSIONS

The systemic administration of rapamycin prolongs corneal allograft survival and significantly inhibits the neovascular component of rejection in the rat model of orthotopic allogeneic penetrating keratoplasty.

Для цитирования: Olsen T W, Benegas N M, Joplin A C, Evangelista T, Mindrup E A, Holland E J. Rapamycin inhibits corneal allograft rejection and neovascularization.. Archives of ophthalmology (Chicago, Ill. : 1960). 1994. DOI: 10.1001/archopht.1994.01090230085026.

Предметные рубрики MeSH

Animals Cornea Corneal Neovascularization Graft Rejection Graft Survival Injections, Intramuscular Keratoplasty, Penetrating Polyenes Rats Rats, Inbred BN Rats, Inbred Lew Sirolimus Transplantation, Homologous

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