The European journal of surgery = Acta chirurgica · 2001
Isosorbide dinitrate in the treatment of anal fissure: a randomised, prospective, double blind, placebo-controlled trial.
Клиническое исследованиеСтатьяРандомизированное исследованиеНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Werre A J, Palamba H W, Bilgen E J, Eggink W F
Аннотация
OBJECTIVE: To assess the efficacy of isosorbide dinitrate in healing anal fissures.
DESIGN: Randomised, prospective, double blind, placebo controlled trial.
SETTING: Teaching hospital, The Netherlands.
SUBJECTS: 37 consecutive subjects with anal fissure diagnosed in the surgical outpatient department.
INTERVENTIONS: After randomisation, 20 patients were given isosorbide dinitrate, and 17 patients placebo.
MAIN OUTCOME MEASURES: Healing of anal fissure, recurrence, and tolerance.
RESULTS: Both groups were treated for a median (range) of 5 weeks (range 1-10). After this period, 17 in the isosorbide group had healed compared with 6 controls (p < 0.003). The fissure recurred in 2 patients who had had an initial good response to isosorbide, and in 2 in the control group. Side effects (particularly headache) were more common after isosorbide dinitrate, but not significantly so (9/20 compared with 3/17).
CONCLUSIONS: Isosorbide dinitrate is an effective treatment for anal fissure, and is significantly better than placebo.
DESIGN: Randomised, prospective, double blind, placebo controlled trial.
SETTING: Teaching hospital, The Netherlands.
SUBJECTS: 37 consecutive subjects with anal fissure diagnosed in the surgical outpatient department.
INTERVENTIONS: After randomisation, 20 patients were given isosorbide dinitrate, and 17 patients placebo.
MAIN OUTCOME MEASURES: Healing of anal fissure, recurrence, and tolerance.
RESULTS: Both groups were treated for a median (range) of 5 weeks (range 1-10). After this period, 17 in the isosorbide group had healed compared with 6 controls (p < 0.003). The fissure recurred in 2 patients who had had an initial good response to isosorbide, and in 2 in the control group. Side effects (particularly headache) were more common after isosorbide dinitrate, but not significantly so (9/20 compared with 3/17).
CONCLUSIONS: Isosorbide dinitrate is an effective treatment for anal fissure, and is significantly better than placebo.