Anxiety and depression in keratotic oral lichen planus: a multicentric study from the SIPMO.
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Adamo Daniela, Calabria Elena, Canfora Federica, Coppola Noemi, Leuci Stefania, Mignogna Martina, Muzio Lorenzo Lo, Spirito Francesca, Giuliani Michele, Azzi Lorenzo, Dani Marta, Colella Giuseppe, Colella Chiara, Montebugnoli Lucio, Gissi Davide Bartolomeo, Gabriele Mario, Nisi Marco, Sardella Andrea, Lodi Giovanni, Varoni Elena Maria, Giudice Amerigo, Antonelli Alessandro, Gambino Alessio, Antonucci Giuliana, Vescovi Paolo, Meleti Marco, Majorana Alessandra, Bardellini Elena, Campisi Giuseppina, Panzarella Vera, Spadari Francesco, Garagiola Umberto, Pentenero Monica, Sutera Samuele, Biasotto Matteo, Ottaviani Giulia, Gobbo Margherita, Nardini Luca Guarda, Romeo Umberto, Tenore Gianluca, Serpico Rosario, Lucchese Alberta, Lajolo Carlo, Gioco Gioele, Aria Massimo, D'Aniello Luca, Mignogna Michele Davide, SIPMO (Italian Society of Oral Pathology, Medicine)
Аннотация
METHODS: Three hundred K-OLP patients versus 300 healthy controls (HC) were recruited in 15 Italian universities. The Numeric Rating Scale (NRS), Total Pain Rating Index (T-PRI), and Hamilton Rating Scales for Depression and for Anxiety (HAM-D and HAM-A) were administered.
RESULTS: The K-OLP patients showed statistically higher scores in the NRS, T-PRI, HAM-D, and HAM-A compared with the HC (p-value < 0.001**). A and D were found in 158 (52.7%) and 148 (49.3%) K-OLP patients. Strong linear correlations were identified between HAM-A, HAM-D, NRS, T-PRI, and employment status and between HAM-D, HAM-A, NRS, T-PRI, employment status, and female gender. Multivariate logistic regression revealed that HAM-D and HAM-A showed the greatest increase in the R2 value for A and D in the K-OLP patients, respectively (DR2 = 55.5% p-value < 0.001**; DR2 = 56.5% p-value < 0.001**).
CONCLUSIONS: The prevalence of A and D is higher in the K-OLP patients compared with the HC, also found in K-OLP subjects without pain, suggesting that the processing of pain may be in a certain way independent of the processing of mood.
CLINICAL RELEVANCE: Mood disorders and pain assessment should be carefully performed in relation to K-OLP to obtain a complete analysis of the patients.