Medicine · 2026
Preoperative albumin-to-globulin ratio as a prognostic factor in patients undergoing curative hepatectomy for hepatocellular carcinoma: A systematic review and meta-analysis.
СтатьяСистематический обзорМетаанализНазвание и аннотация: Перевод пока не подготовлен
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Utsumi Masashi, Inagaki Masaru, Omoto Koki, Onoda Naoki, Kitada Koji, Tokunaga Naoyuki, Okabayashi Hiroki, Hamano Ryosuke, Miyaso Hideaki, Tsunemitsu Yosuke, Otsuka Shinya
Аннотация
BACKGROUND: The albumin-to-globulin ratio (AGR) has emerged as a novel inflammation-based prognostic marker in various cancers; however, a comprehensive and quantitative assessment of its prognostic role in hepatocellular carcinoma (HCC) is lacking. Therefore, we conducted this meta-analysis to assess the prognostic value of the preoperative AGR in patients with HCC.
METHODS: We systematically reviewed the literature for studies reporting the prognostic impact of AGR in patients undergoing curative hepatectomy for HCC. Random-effects meta-analyses of overall survival (OS) and recurrence-free survival were performed.
RESULTS: Six studies involving 2107 patients were included in this meta-analysis, with all conducted in Asian populations. Four studies were conducted in China, whereas 2 studies were conducted in Japan. Low pretreatment AGR was significantly correlated with decreased OS (hazard ratio: 1.69, 95% confidence interval: 1.37-2.08, P < .001) and recurrence-free survival (hazard ratio: 1.62, 95% confidence interval: 1.37-1.91, P < .001). Subgroup analyses suggested that a low AGR predicted decreased OS in patients with HCC, regardless of region, sample size, age, and cutoff values.
CONCLUSION: Low preoperative AGR was significantly associated with poor prognosis of patients with HCC. AGR may serve as a prognostic biomarker, although validation in prospective cohorts is required.
METHODS: We systematically reviewed the literature for studies reporting the prognostic impact of AGR in patients undergoing curative hepatectomy for HCC. Random-effects meta-analyses of overall survival (OS) and recurrence-free survival were performed.
RESULTS: Six studies involving 2107 patients were included in this meta-analysis, with all conducted in Asian populations. Four studies were conducted in China, whereas 2 studies were conducted in Japan. Low pretreatment AGR was significantly correlated with decreased OS (hazard ratio: 1.69, 95% confidence interval: 1.37-2.08, P < .001) and recurrence-free survival (hazard ratio: 1.62, 95% confidence interval: 1.37-1.91, P < .001). Subgroup analyses suggested that a low AGR predicted decreased OS in patients with HCC, regardless of region, sample size, age, and cutoff values.
CONCLUSION: Low preoperative AGR was significantly associated with poor prognosis of patients with HCC. AGR may serve as a prognostic biomarker, although validation in prospective cohorts is required.