[Clinical significance and expression of periostin in chronic rhinosinusitis with nasal polyps].

Objective

To investigate the clinical significance and expression of periostin in chronic rhinosinusitis with nasal polyps（CRSwNP） . Method:In this study, we collected 30 CRSwNP patients' nasal polyps（NPs） and 18 control subjects' normal nasal mucosa of uncinate process. The expressions of periostin and IL-5 were examined using immunohistochemistric staining, immunostaining and /or quantitative RT-PCR and the eosinophil infiltration were evaluated as well. Result:Periostin was mainly expressed in the subdermal area of nasal mucosa. The number of periostin positive cells in nasal polyps was significantly higher than that in normal control group（P<0.01）. The mRNA and protein expressions of periostin in NPs were significantly higher than that of the control nasal mucosa（all P<0.01）. The expression of priostin mRNA were positively correlated with IL-5 expression in NPs（r=0.731 5, P<0.01）.

Conclusion

Our findings indicate periostin may participate in the formation of nasal polyps by means of chemostaxis and activation of eosinophils.