Balkan medical journal · 2013
A Case Report on Aspergillus lentulus Pneumonia.
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Gürcan Saban, Tikveşli Melek, Ustündağ Sedat, Ener Beyza
Аннотация
BACKGROUND: Aspergillus lentulus was described as a new species in 2005 but it was isolated from Turkey for the first time.
CASE REPORT: A. lentulus was isolated as the cause of pneumonia from a patient who had renal transplantation 4 months ago. The patient received immunosuppressive treatment after transplantation. A. lentulus was isolated from his sputum as an agent in pneumonia developed 4 months after the transplantation. Leukocytes, blastospores, and hyphae were seen in both Gram- and Giemsastained smears of the sputum. The isolate was identified by using the Maren A. Klich algorithm and molecular methods and confirmed by the reference laboratory of the CBS Fungal Biodiversity Centre (The Netherlands). In the susceptibility tests of the isolate, minimal inhibitory concentrations for amphotericin B, voriconazole, posaconazole, and caspofungin were found to be 0.5 μg/mL, 0.25 μg/mL, 0.125 μg/mL, and 0.25 μg/mL, respectively. The patient recovered with voriconazole treatment (2×200 mg/day).
CONCLUSION: The use of the molecular tests is important for identification of A. lentulus strains because they are very easily confused with A.fumigatus strains according to phenotypic characteristics.
CASE REPORT: A. lentulus was isolated as the cause of pneumonia from a patient who had renal transplantation 4 months ago. The patient received immunosuppressive treatment after transplantation. A. lentulus was isolated from his sputum as an agent in pneumonia developed 4 months after the transplantation. Leukocytes, blastospores, and hyphae were seen in both Gram- and Giemsastained smears of the sputum. The isolate was identified by using the Maren A. Klich algorithm and molecular methods and confirmed by the reference laboratory of the CBS Fungal Biodiversity Centre (The Netherlands). In the susceptibility tests of the isolate, minimal inhibitory concentrations for amphotericin B, voriconazole, posaconazole, and caspofungin were found to be 0.5 μg/mL, 0.25 μg/mL, 0.125 μg/mL, and 0.25 μg/mL, respectively. The patient recovered with voriconazole treatment (2×200 mg/day).
CONCLUSION: The use of the molecular tests is important for identification of A. lentulus strains because they are very easily confused with A.fumigatus strains according to phenotypic characteristics.