Assessing attacks and treatment response rates among adult patients with NMOSD and MOGAD: Data from a nationwide registry in Argentina.
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Contentti Edgar Carnero, Lopez Pablo A, Pettinicchi Juan Pablo, Criniti Juan, Pappolla Agustín, Miguez Jimena, Patrucco Liliana, Carnero Contentti Edgardo, Liwacki Susana, Tkachuk Verónica, Balbuena María E, Vrech Carlos, Deri Norma, Correale Jorge, Marrodan Mariano, Ysrraelit María C, Leguizamon Felisa, Luetic Geraldine, Menichini María L, Tavolini Darío, Mainella Carolina, Zanga Gisela, Burgos Marcos, Hryb Javier, Barboza Andrés, Lazaro Luciana, Alonso Ricardo, Liguori Nora Fernández, Nadur Débora, Chercoff Aníbal, Alonso Serena Marina, Caride Alejandro, Paul Friedemann, Rojas Juan I
Аннотация
METHODS: Retrospective study. Data on patient demographic, clinical and radiological findings, and administered treatments were collected. Remission status (complete [CR], partial [PR], no remission [NR]), based on changes in the EDSS score was evaluated before treatment, during attack, and at 6 months. CR was analyzed with a generalized estimating equations (GEEs) model.
RESULTS: A total of 131 patients (120 NMOSD and 11 myelin oligodendrocyte glycoprotein-antibody-associated diseases [MOGAD]), experiencing 262 NMOSD-related attacks and receiving 270 treatments were included. High-dose steroids (81.4%) was the most frequent treatment followed by plasmapheresis (15.5%). CR from attacks was observed in 47% (105/223) of all treated patients. During the first attack, we observed CR:71.2%, PR:16.3% and NR:12.5% after the first course of treatment. For second, third, fourth, and fifth attacks, CR was observed in 31.1%, 10.7%, 27.3%, and 33.3%, respectively. Remission rates were higher for optic neuritis vs. myelitis (p < 0.001). Predictor of CR in multivariate GEE analysis was age in both NMOSD (OR = 2.27, p = 0.002) and MOGAD (OR = 1.53, p = 0.03).
CONCLUSIONS: This study suggests individualization of treatment according to age and attack manifestation. The outcome of attacks was generally poor.