Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2010
Comparison of reproducibility of manual and sphere contour methods for the measurement of vascularization in cervical carcinoma using the virtual organ computer-aided analysis II system.
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Qin Jiale, Wang Junmei, Lu Weiguo, Li Yuan, Yao Weimiao, Qian Yue
Аннотация
OBJECTIVE: The purpose of this study was to investigate the reproducibility of virtual organ computer-aided analysis II software (GE Healthcare, Milwaukee, WI), an integrated tool for 3-dimensional power Doppler angiography (3D-PDA), in measuring vascularization of cervical carcinoma under manual and automatic sphere contour modes.
METHODS: Eighty patients with cervical carcinoma were prospectively examined by observer 1 using transvaginal 3D-PDA. For each patient, measurements of the vascularization index, flow index, and vascularization-flow index were repeated twice under both manual and automatic sphere contour modes. Forty patients were randomly selected for another round of examination by observer 2 under the same setting. The reproducibility of vascularization measurements was assessed by the intraclass correlation coefficient (intra-CC), interclass correlation coefficient (inter-CC), and 95% limits of agreement (LOAs). Various analysis of variance models were used to estimate the contribution of each factor (observer, contour mode, and patient) to measurement variance.
RESULTS: For each observer, the manual contour mode outperformed the automatic sphere contour mode in reproducibility (intra-CC, 0.96 to 0.99 versus 0.77 to 0.94). In addition, repeated measurements of the manual mode had a smaller SD and a narrower LOA. For the manual contour mode, interobserver agreement was comparable with intraobserver agreement (inter-CC, 0.91 to 0.98, versus intra-CC, 0.96 to 0.99). However, the interobserver agreement was significantly smaller than the intraobserver agreement for the automatic sphere contour mode (inter-CC, 0.51 to 0.85, versus intra-CC, 0.77 to 0.94; P = .001).
CONCLUSIONS: The manual contour mode for 3D-PDA vascular measurements has better interobserver and intraobserver reproducibility than the automatic sphere contour mode. It is especially useful for measuring tumor tissues with irregular shapes and vascularity.
METHODS: Eighty patients with cervical carcinoma were prospectively examined by observer 1 using transvaginal 3D-PDA. For each patient, measurements of the vascularization index, flow index, and vascularization-flow index were repeated twice under both manual and automatic sphere contour modes. Forty patients were randomly selected for another round of examination by observer 2 under the same setting. The reproducibility of vascularization measurements was assessed by the intraclass correlation coefficient (intra-CC), interclass correlation coefficient (inter-CC), and 95% limits of agreement (LOAs). Various analysis of variance models were used to estimate the contribution of each factor (observer, contour mode, and patient) to measurement variance.
RESULTS: For each observer, the manual contour mode outperformed the automatic sphere contour mode in reproducibility (intra-CC, 0.96 to 0.99 versus 0.77 to 0.94). In addition, repeated measurements of the manual mode had a smaller SD and a narrower LOA. For the manual contour mode, interobserver agreement was comparable with intraobserver agreement (inter-CC, 0.91 to 0.98, versus intra-CC, 0.96 to 0.99). However, the interobserver agreement was significantly smaller than the intraobserver agreement for the automatic sphere contour mode (inter-CC, 0.51 to 0.85, versus intra-CC, 0.77 to 0.94; P = .001).
CONCLUSIONS: The manual contour mode for 3D-PDA vascular measurements has better interobserver and intraobserver reproducibility than the automatic sphere contour mode. It is especially useful for measuring tumor tissues with irregular shapes and vascularity.