Nature communications · 2019
Three phylogenetic groups have driven the recent population expansion of Cryptococcus neoformans.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Ashton P M, Thanh L T, Trieu P H, Van Anh D, Trinh N M, Beardsley J, Kibengo F, Chierakul W, Dance D A B, Rattanavong S, Davong V, Hung L Q, Chau N V V, Tung N L N, Chan A K, Thwaites G E, Lalloo D G, Anscombe C, Nhat L T H, Perfect J, Dougan G, Baker S, Harris S, Day J N
Аннотация
Cryptococcus neoformans (C. neoformans var. grubii) is an environmentally acquired pathogen causing 181,000 HIV-associated deaths each year. We sequenced 699 isolates, primarily C. neoformans from HIV-infected patients, from 5 countries in Asia and Africa. The phylogeny of C. neoformans reveals a recent exponential population expansion, consistent with the increase in the number of susceptible hosts. In our study population, this expansion has been driven by three sub-clades of the C. neoformans VNIa lineage; VNIa-4, VNIa-5 and VNIa-93. These three sub-clades account for 91% of clinical isolates sequenced in our study. Combining the genome data with clinical information, we find that the VNIa-93 sub-clade, the most common sub-clade in Uganda and Malawi, was associated with better outcomes than VNIa-4 and VNIa-5, which predominate in Southeast Asia. This study lays the foundation for further work investigating the dominance of VNIa-4, VNIa-5 and VNIa-93 and the association between lineage and clinical phenotype.