Clinical nuclear medicine · 2018
Fatal Intracranial Hemorrhage Due to Thrombocytopenia in a Patient With Castration-Resistant Prostate Cancer Showing Extensive Bone Uptake of Injected 223Ra Dichloride.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Nakahara Tadaki, Owaki Yoshiki, Kosaka Takeo, Fukada Junichi, Ichimura Akira, Jinzaki Masahiro
Аннотация
A 64-year-old man with castration-resistant prostate cancer received Ra injection to treat bone metastases. The patient underwent a Ra SPECT scan after the first Ra injection in which there was increased uptake all over the spine. Spine-to-background activity ratio in the patient was approximately three times greater than normal spine-to-background activity ratios in Ra SPECT obtained from the other patients. Eight days after the fifth injection, the patient exhibited a very poor neurologic examination and died of intracranial hemorrhage due to severe thrombocytopenia (platelet counts, 23,000/mm). The extensive radiation to the spine may have enhanced myelophthisic process in this case.