[Depressive state of rats in conditions of chronic combined stress caused by the combination of differently modal stressors].

Chronic combined stress with the change of differently modal stressors (noise, vibration and pulsating bright light) according to the stochastic scheme against the background of constant stressors (restriction of movement, fluctuations of the temperature of the environment) causes symptoms of depression-like animal behavior, having the pronounced phenomenological simila rity with the clinical presentation of depression: anxiety, behavioral correlates of despair, hypodynamia, anhedonia, as well as morphosomatic consequences of chronic stress: involution of the thymus and spleen, hypertrophy of epinephros, ulceration of the mucous stomach membrane. Imipramine and fluoxetine effectively reduce the stated behavioral disorders, their effectiveness corresponds to the results of clinical studies and the data received from other models of depression. The described model of depression, has satisfactory, corresponding, constructive and predictive validity and can be used for physiological, ethological, and pharmacological studies.