Diabetes research and clinical practice · 2025
Autonomic function and hemodynamic changes in type 2 diabetes: insights into sympathetic activation and vascular stiffness.
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Costa Larissa Morete Caieiro da, Minari Tatiana Palotta, Pisani Luciana Pellegrini, de Azevedo Rubio Tatiane, Yugar Louise Bounalume Tácito, Sedenho-Prado Luis Gustavo, Ribeiro Milene, Tacito Lúcia Helena Bonalume, Cosenso-Martin Luciana Neves, Pires Antônio Carlos, Moreno Heitor, Vilela-Martin José Fernando, Yugar-Toledo Juan Carlos
Аннотация
AIMS: This study aimed to investigate the relationship between autonomic function, arterial stiffness, and vascular compliance in patients with type 2 diabetes (T2D).
METHODS: Eighty-one T2D patients were divided into two groups based on disease duration: <10 years (N = 50) and >10 years (N = 31). Autonomic function was assessed via heart rate variability, and vascular hemodynamics via pulse wave velocity (PWV). Linear and multivariate regression analyses explored associations between autonomic function and vascular parameters.
RESULTS: Female participants predominated, accounting for 60 % in the <10 years group and 64.5 % in the >10 years group. Comorbidities were present in 67.7 % of the <10 years group and 70 % of the >10 years group. Biochemical differences were minimal, except for a significant albumin/creatinine ratio in the >10 years group (p = 0.007). Central hemodynamics showed no significant differences, but sympathetic activity correlated with diastolic blood pressure (DBP) during wakefulness (r = 0.45, p = 0.003).
CONCLUSIONS: While no direct correlation was found between arterial stiffness and autonomic function, increased sympathetic activation was linked to higher DBP. Early screening, lifestyle modifications, and targeted treatments could improve patient outcomes and T2D management.
METHODS: Eighty-one T2D patients were divided into two groups based on disease duration: <10 years (N = 50) and >10 years (N = 31). Autonomic function was assessed via heart rate variability, and vascular hemodynamics via pulse wave velocity (PWV). Linear and multivariate regression analyses explored associations between autonomic function and vascular parameters.
RESULTS: Female participants predominated, accounting for 60 % in the <10 years group and 64.5 % in the >10 years group. Comorbidities were present in 67.7 % of the <10 years group and 70 % of the >10 years group. Biochemical differences were minimal, except for a significant albumin/creatinine ratio in the >10 years group (p = 0.007). Central hemodynamics showed no significant differences, but sympathetic activity correlated with diastolic blood pressure (DBP) during wakefulness (r = 0.45, p = 0.003).
CONCLUSIONS: While no direct correlation was found between arterial stiffness and autonomic function, increased sympathetic activation was linked to higher DBP. Early screening, lifestyle modifications, and targeted treatments could improve patient outcomes and T2D management.