Molecular mechanisms underlying resistance to antimalarial compounds.

Drug resistance poses a major challenge to malaria control. Multiple strategies enable Plasmodium, the causative agent of malaria, to develop resistance against a broad range of antimalarial drugs. Comprehensive understanding of these mechanisms is crucial, not only for anticipating future threats but also for identifying molecular markers that can be used to monitor the emergence of drug resistance in field populations. This review summarizes the diverse pathways by which the parasite develops resistance, with a particular focus on recent mechanisms and next-generation antimalarial drugs under development.