LncRNA signature associated with amino acid metabolism: A novel prognostic tool for Clear Cell Renal Cell Carcinoma.

The progression of clear cell renal cell carcinoma (ccRCC) is influenced by amino acid metabolism (AAM) and long non-coding RNAs (lncRNAs). However, the prognostic significance of AAM-related lncRNAs (AAMLRs) in ccRCC remains to be further investigated. The AAMLRs signature were constructed via univariate Cox and LASSO analyses, which was validated in a local cohort. Herein, we found that patients with low risk scores showed longer survival time than those with high risk scores. Several immune checkpoints were upregulated in the patients classified as high-risk group. Differences were observed between the high- and low-risk groups in terms of immune cell subtypes, including CD8+ T cells, macrophages, and NK cells. High-risk patients showed increased drug sensitivity towards 5-fluorouracil, paclitaxel, vorinostat, sorafenib, and cisplatin. In conclusion, we demonstrated that the prognostic AAMLRs signature acts as a prognostic predictor in ccRCC and provide novel insights into treatment.