[Morphologic and histochemical changes of skin nervous apparatus in wound healing following local action of noradrenaline and acetylcholine].

The effect of noradrenaline and acetylcholine on the innervation of skin regenerates in albino rats was studied. It was demonstrated that noradrenaline increased resistive capacity of skin nerve elements to trauma and decelerated the degeneration of impaired elements; promoted skin regenerate neurotization, nerve fibres sprouting and tropism to epidermis; increased monoamine oxidase activity and catecholamine content in adrenergic nerve fibres. Acetylcholine decreases the nerve elements resistive capacity to trauma and accelerates degenerative processes, amplifies peripheral glia reaction; decelerates and activity in appropriate conductors and causes the appearance of basket like plexuses around epidermal invaginating outgrowths.