Intravenous immunoglobulin replacement therapy for common variable immunodeficiency during pregnancy.

Patients with common variable immunodeficiency (CVID), characterized by impaired antibody production, have a high susceptibility to bacterial infections and need supplements of immunoglobulin G (IgG). We report two pregnancies in a woman with CVID. Differences in the outcome of the two pregnancies suggest the need for adjustment of replacement therapy during pregnancy.