[Incidence of hypogammaglobulinemia in patients with nonspecific lung diseases].

Patients with hypogammaglobulinemia frequently show complications of the respiratory tract system. We analyzed electrophoresises in 1087 patients with acute and chronic non-specific lung diseases. It were found 14 cases (1,3%) of reproducible hypogammaglobulinemias with pathologic decrease of immunoglobulinfractions in immunoelectrophoresis. All cases could be confirmed as genetically determined by anamnesis and examinations of relatives. The frequency of primary immunodefects and in adults manifesting cases of "common variable immunodeficiency (CVID)" is given in literature with 10:10(6) for the whole population. We found in our patients with non-specific disorders an 1000 x increased incidence.