Annals of clinical microbiology and antimicrobials · 2024
The epidemiology of gram-negative bacteremia in Lebanon: a study in four hospitals.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Nasr Janane, Abdessamad Hilal, Mina Johnathan, Haykal Tony, Jamil Yasser, Abboud Emma, Mahdi Ahmad, Asmar Rana, Abi Assaad Rawad, Alameddine Dana, Bourji Alaa, Mahdi Mahmoud, Abdulaal Razan, Tomassian Serge, El Ahmadieh Hanane, Azzam Wael, Mokhbat Jacques E, Moghnieh Rima, Rodriguez-Morales Alfonso J, Husni Rola
Аннотация
INTRODUCTION: Gram-negative bacteremia is a life-threatening infection with high morbidity and mortality. Its incidence is rising worldwide, and treatment has become more challenging due to emerging bacterial resistance. Little data is available on the burden and outcome of such infections in Lebanon.
METHODS: We conducted this retrospective study in four Lebanese hospitals. Data on medical conditions and demographics of 2400 patients diagnosed with a bloodstream infection based on a positive blood culture were collected between January 2014 and December 2020.
RESULTS: Most bacteremias were caused by Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii, with the more resistant organisms being hospital-acquired. Third-generation cephalosporin and quinolone resistance was steady throughout the study, but carbapenem resistance increased. Mortality with such infections is high, but carbapenem resistance or infection with Pseudomonas or Acinetobacter species were significant risk factors for poor outcomes.
CONCLUSION: This is the first multi-center study from Lebanon on gram-negative bacteremia, resistance patterns, and factors associated with a poor outcome. More surveillance is needed to provide data to guide empirical treatment for bacteremia in Lebanon.
METHODS: We conducted this retrospective study in four Lebanese hospitals. Data on medical conditions and demographics of 2400 patients diagnosed with a bloodstream infection based on a positive blood culture were collected between January 2014 and December 2020.
RESULTS: Most bacteremias were caused by Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii, with the more resistant organisms being hospital-acquired. Third-generation cephalosporin and quinolone resistance was steady throughout the study, but carbapenem resistance increased. Mortality with such infections is high, but carbapenem resistance or infection with Pseudomonas or Acinetobacter species were significant risk factors for poor outcomes.
CONCLUSION: This is the first multi-center study from Lebanon on gram-negative bacteremia, resistance patterns, and factors associated with a poor outcome. More surveillance is needed to provide data to guide empirical treatment for bacteremia in Lebanon.
Предметные рубрики MeSH
HumansLebanonBacteremiaRetrospective StudiesMaleFemaleGram-Negative Bacterial InfectionsMiddle AgedAnti-Bacterial AgentsGram-Negative BacteriaAgedHospitalsAdultCross InfectionPseudomonas aeruginosaMicrobial Sensitivity TestsKlebsiella pneumoniaeDrug Resistance, BacterialAged, 80 and overRisk FactorsAcinetobacter baumannii