Insulin-like growth factor-1 (IGF-1) as predictor of cardiovascular mortality in heart failure patients: data from the T.O.S.CA. registry.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
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De Giorgi Alfredo, Marra Alberto Maria, Iacoviello Massimo, Triggiani Vincenzo, Rengo Giuseppe, Cacciatore Francesco, Maiello Ciro, Limongelli Giuseppe, Masarone Daniele, Perticone Francesco, Filardi Pasquale Perrone, Paolillo Stefania, Mancini Antonio, Volterrani Maurizio, Vriz Olga, Castello Roberto, Passantino Andrea, Campo Michela, Modesti Pietro Amedeo, Salzano Andrea, D'Assante Roberta, Arcopinto Michele, Raparelli Valeria, Fabbian Fabio, Sciacqua Angela, Colao Annamaria, Suzuki Toru, Bossone Eduardo, Cittadini Antonio, T.O.S.CA. Investigators
Аннотация
METHODS: At the enrolment, all subjects underwent chemistry examinations, including circulating hormones and cardiovascular functional tests. COX regression analysis was used to evaluate factors related to CVM during the follow-up period in all populations, in high-risk patients and in the young-adult population. Also, we evaluate the effects of renal function on the CVM.
RESULTS: 337 patients (41 deceased) were analyzed. CVM was related to severe renal dysfunction (HR stages IV-V = 4.86), high-risk conditions (HR 2.25), serum IGF-1 (HR 0.42), and HF etiology (HR 5.85 and HR 1.63 for valvular and ischemic etiology, respectively). In high-risk patients, CVM was related to IGF-1 levels, severe renal dysfunction and valvular etiology, whereas in young patients CMV was related to the high-risk pattern and serum IGF-1 levels.
CONCLUSIONS: Our study showed the clinical and prognostic utility of the IGF-1 assay in patients with HF.