Frontiers in public health · 2025
Dabie bandavirus identified from patients with severe fever with thrombocytopenia syndrome in northwestern of Hubei Province, China, 2024.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Zhang Mengzhu, Fu Peixi, Meng ZhongJi, He Yuqian, Qin Xueqin, Luo Sen, Xu Yunzhen, Liu Li, Qiu Guangyu, Liu Yang, Peng Yanli, Song Fangmin, Xu Tianyi, Yin Jiao, Liu Mingming, Wang Chuanmin
Аннотация
INTRODUCTION: Severe fever with thrombocytopenia syndrome (SFTS), caused by Dabie bandavirus (DBV), is a zoonotic disease characterized by substantial mortality. Hubei Province is an epidemic region with a high incidence rate of SFTS. The clinical manifestations and case fatality rates (CFRs) of SFTS correlate with specific geographic regions and genotypes of DBV.
METHODS: From January to December 2024, serum samples were obtained from 69 patients with suspected DBV infection in northwestern Hubei Province, China. The presence of DBV RNA was used as the diagnostic criterion for SFTS. Demographic characteristics, clinical manifestations, and laboratory findings of confirmed SFTS patients were systematically collected. Phylogenetic analyses of the DBV L, M, and S gene segments were performed using the maximum likelihood method to elucidate the genetic diversity of the viral isolates.
RESULTS: A total of 19 patients with confirmed SFTS were identified in northwestern Hubei Province in 2024, with a CFR of 31.6% (6/19). Clinical analyses indicated that bleeding, disturbance of consciousness, prolonged activated partial thromboplastin time (APTT), elevated blood urea nitrogen (BUN), and high viral load (≥107 copies/mL) were critical prognostic indicators of disease severity. Maximum likelihood phylogenetic analyses of the L, M, and S gene segments demonstrated that genotype F was the predominant lineage circulating in this region.
DISCUSSION: This study delineates the genomic diversity and genotype distribution of circulating DBV strains, providing insights into viral etiology in northwestern Hubei. Furthermore, specific clinical/laboratory markers may signal adverse outcomes, emphasizing the imperative for symptom recognition and dynamic monitoring of critical laboratory parameters.
METHODS: From January to December 2024, serum samples were obtained from 69 patients with suspected DBV infection in northwestern Hubei Province, China. The presence of DBV RNA was used as the diagnostic criterion for SFTS. Demographic characteristics, clinical manifestations, and laboratory findings of confirmed SFTS patients were systematically collected. Phylogenetic analyses of the DBV L, M, and S gene segments were performed using the maximum likelihood method to elucidate the genetic diversity of the viral isolates.
RESULTS: A total of 19 patients with confirmed SFTS were identified in northwestern Hubei Province in 2024, with a CFR of 31.6% (6/19). Clinical analyses indicated that bleeding, disturbance of consciousness, prolonged activated partial thromboplastin time (APTT), elevated blood urea nitrogen (BUN), and high viral load (≥107 copies/mL) were critical prognostic indicators of disease severity. Maximum likelihood phylogenetic analyses of the L, M, and S gene segments demonstrated that genotype F was the predominant lineage circulating in this region.
DISCUSSION: This study delineates the genomic diversity and genotype distribution of circulating DBV strains, providing insights into viral etiology in northwestern Hubei. Furthermore, specific clinical/laboratory markers may signal adverse outcomes, emphasizing the imperative for symptom recognition and dynamic monitoring of critical laboratory parameters.