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DOI 10.1126/science.adx6925

Медицинская библиотека · Science (New York, N.Y.) · 2026

The origin, history, and resistance architecture of an invasive urban malaria mosquito in Africa.

Dennis Tristan P W, Sulieman Jihad Eltaher, Nouredayem Mujahid, Ashine Temesgen, Ebstie Yehenew, Eyasu Adane, Simma Eba A, Zemene Endalew, Negash Nigatu, Yigeremu Abena, Assefa Muluken, Elzack Hamza, Dagne Alemayehu, Lukas Biniam, Bulto Mikiyas Gebremichael, Fontaine Michael C, Talignani Loïc, Enayati Ahmadali, Nikpoor Fatemeh, Al-Nazawi Ashwaq M, Al-Zahrani Mohammed H, Khaireh Bouh Abdi, Guelleh Samatar, Abdi Abdoul-Ilah Ahmed, Allan Richard, Omondi Seline, Abong'o Bernard, Milanoi Sylvia, Ochomo Eric, Ahmed Ayman, Samake Jeanne N, Gimnig John E, Rafferty Cristina, Ashraf Faisal, Pignatelli Patricia, Morris Marion, Nagi Sanjay C, Lucas Eric R, Hernandez-Koutoucheva Anastasia, Clarkson Chris S, Doumbe-Belisse Patricia, Epstein Adrienne, Brown Rebecca, Wilson Anne L, Reynolds Alison M, Sherrard-Smith Ellie, Yewhalaw Delenasaw, Gadisa Endalamaw, Malik Elfatih, Kafy Hmooda Toto, Donnelly Martin J, Weetman David

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Аннотация

The invasive urban malaria vector Anopheles stephensi threatens 126 million city dwellers in Africa. Controlling An. stephensi requires greater understanding of its origin, invasion dynamics, and insecticide resistance mechanisms. Analysis of 645 whole genomes sampled across Africa, the Middle East, and Asia supports an invasion scenario in which an initial South Asian introduction established a bridgehead population in Djibouti, which seeded distinct invasion fronts in Sudan, Ethiopia/Kenya, and Yemen. These incursions show contrasting rates and routes of spread shaped by landscape topology. Insecticide resistance is predominantly mediated by metabolic detoxification genes, with resistance haplotypes and copy-number amplifications introduced from South Asia. These findings, alongside a companion genomic resource, enable genomic surveillance of An. stephensi spread and resistance to aid control strategies.

Для цитирования: Dennis Tristan P W, Sulieman Jihad Eltaher, Nouredayem Mujahid, Ashine Temesgen, Ebstie Yehenew, Eyasu Adane, Simma Eba A, Zemene Endalew, Negash Nigatu, Yigeremu Abena, Assefa Muluken, Elzack Hamza, Dagne Alemayehu, Lukas Biniam, Bulto Mikiyas Gebremichael, Fontaine Michael C, Talignani Loïc, Enayati Ahmadali, Nikpoor Fatemeh, Al-Nazawi Ashwaq M, Al-Zahrani Mohammed H, Khaireh Bouh Abdi, Guelleh Samatar, Abdi Abdoul-Ilah Ahmed, Allan Richard, Omondi Seline, Abong'o Bernard, Milanoi Sylvia, Ochomo Eric, Ahmed Ayman, Samake Jeanne N, Gimnig John E, Rafferty Cristina, Ashraf Faisal, Pignatelli Patricia, Morris Marion, Nagi Sanjay C, Lucas Eric R, Hernandez-Koutoucheva Anastasia, Clarkson Chris S, Doumbe-Belisse Patricia, Epstein Adrienne, Brown Rebecca, Wilson Anne L, Reynolds Alison M, Sherrard-Smith Ellie, Yewhalaw Delenasaw, Gadisa Endalamaw, Malik Elfatih, Kafy Hmooda Toto, Donnelly Martin J, Weetman David. The origin, history, and resistance architecture of an invasive urban malaria mosquito in Africa.. Science (New York, N.Y.). 2026. DOI: 10.1126/science.adx6925.

Предметные рубрики MeSH

AnimalsAnophelesInsecticide ResistanceMalariaAfricaIntroduced SpeciesMosquito VectorsGenome, InsectHaplotypesInsecticidesAsia, SouthernMiddle East
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