European journal of haematology · 2025
Characteristics and Clinical Outcomes of Multiple Myeloma in Adolescents and Young Adults.
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Olafimihan Ayobami, Nwachukwu Chiamaka, Jackson Inimfon, Ogedegbe Oboseh John, Ntukidem Olanipekun Lanny, Fawehinmi Praise, Shaka Hafeez, Mba Benjamin, Farooqui Marwah Wafa
Аннотация
INTRODUCTION: Though evidence suggests that multiple myeloma (MM) in adolescents and young adults (AYA) (< 50 years) has significant biological differences from that in older individuals (≥ 50 years), the understanding of the disease in this group is limited. We examined the outcomes in AYA hospitalizations with MM.
METHODS: Using the National Inpatient Sample database, we examined sociodemographic, hospital-level, and clinical characteristics between AYA and older populations with MM.
RESULTS: Among 183 846 non-elective MM hospitalizations, 13 765 (7.5%) were AYA. There was a higher proportion of males in the AYA group compared to the older group (58.6% vs. 54.8%, p < 0.001) but a lower distribution of non-Hispanic Whites (40.6% vs. 56.7%, p < 0.001). The AYA group had lower odds of mortality (aOR: 0.59, p < 0.001) relative to the older adult group. They were more likely to receive autologous stem cell transplantation (aOR: 1.80, p < 0.001) but had similar odds of acute venous thromboembolism (aOR: 0.87; p = 0.24) and severe sepsis (aOR: 0.89; p = 0.52).
CONCLUSION: We highlight the unique characteristics and outcomes of AYA-MM, emphasizing the need for their greater representation in clinical research. Additionally, we underscore the importance of further investigation to better understand and optimize survivorship care in AYA patients with MM.
METHODS: Using the National Inpatient Sample database, we examined sociodemographic, hospital-level, and clinical characteristics between AYA and older populations with MM.
RESULTS: Among 183 846 non-elective MM hospitalizations, 13 765 (7.5%) were AYA. There was a higher proportion of males in the AYA group compared to the older group (58.6% vs. 54.8%, p < 0.001) but a lower distribution of non-Hispanic Whites (40.6% vs. 56.7%, p < 0.001). The AYA group had lower odds of mortality (aOR: 0.59, p < 0.001) relative to the older adult group. They were more likely to receive autologous stem cell transplantation (aOR: 1.80, p < 0.001) but had similar odds of acute venous thromboembolism (aOR: 0.87; p = 0.24) and severe sepsis (aOR: 0.89; p = 0.52).
CONCLUSION: We highlight the unique characteristics and outcomes of AYA-MM, emphasizing the need for their greater representation in clinical research. Additionally, we underscore the importance of further investigation to better understand and optimize survivorship care in AYA patients with MM.