Changing delayed-type sensitizations to the baseline series allergens over a decade at the Zurich University Hospital.

BACKGROUND

Patch testing detects delayed-type sensitizations and may show changes in prevalence over time.

OBJECTIVES

To compare sensitization prevalence to our baseline series allergens during the years 2000-2004 to results from 1990 to 1994.

METHODS

We analysed baseline patch test series allergens from 2000 through 2004.

RESULTS

4094 individuals were patch tested to the baseline series (mean age 45.4 years, males 41.7%). The highest sensitization rates were found for nickel sulfate (19.3%), fragrance mix (10.4%) and Myroxylon pereirae (7.8%). Compared to 1990-1994, methylchloroisothiazolinone (and) methylisothiazoline (MCI/MI) and neomycin sulfate sensitization decreased and lanolin alcohol, thiuram mix and ammoniated mercury sensitization increased.

CONCLUSIONS

Current sensitization rates are similar to those across Europe. Reduced sensitizations to MCI/MI and neomycin sulfate and increased sensitizations to thiuram mix and ammoniated mercury chloride may well be because of changes in exposure. The current group comprises a higher proportion affected by leg dermatitis and may thus explain the higher sensitization to lanolin alcohol. Comparing patch results over time shows important changes in sensitization prevalence.