ACS infectious diseases · 2023
Screen for New Antimicrobial Natural Products from the NCI Program for Natural Product Discovery Prefractionated Extract Library.
СтатьяResearch Support, N.I.H., IntramuralПоддержка NIH: внешняя программаНазвание и аннотация: Перевод пока не подготовлен
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Martínez-Fructuoso Lucero, Arends S J Ryan, Freire Vitor F, Evans Jason R, DeVries Sean, Peyser Brian D, Akee Rhone K, Thornburg Christopher C, Kumar Rohitesh, Ensel Susan, Morgan Gina M, McConachie Grant D, Veeder Nathan, Duncan Leonard R, Grkovic Tanja, O'Keefe Barry R
Аннотация
The continuing emergence of antibiotic-resistant microbes highlights the need for the identification of new chemotypes with antimicrobial activity. One of the most prolific sources of antimicrobial molecules has been the systematic screening of natural product samples. The National Institute of Allergy and Infectious Diseases and the National Cancer Institute here report a large screen of 326,656 partially purified natural product fractions against a panel of four microbial pathogens, resulting in the identification of >3000 fractions with antifungal and/or antibacterial activity. A small sample of these active fractions was further purified and the chemical structures responsible for the antimicrobial activity were elucidated. The proof-of-concept study identified many different chemotypes, several of which have not previously been reported to have antimicrobial activity. The results show that there remain many unidentified antibiotic compounds from nature.