Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2025
Safety of bariatric surgery in HIV-positive patients on antiretroviral therapy.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Aitharaju Varun, Sierra Leandro, Syed Ali, Flora Bailey, Staneff Erika, Chatterjee Arjun, Khurana Akash, Patel Roma, Firkins Stephen, Simons-Linares Roberto
Аннотация
BACKGROUND: Obesity among people living with HIV (PLWH) is rising, but the safety of bariatric surgery in this population remains unclear. Preliminary evidence suggests that bariatric surgery does not exacerbate HIV progression or elevate postoperative risk.
OBJECTIVES: This study aimed to compare the risk of all-cause mortality and inpatient admission between HIV-positive and HIV-negative patients undergoing bariatric surgery. Secondary aims included evaluating adverse events (sepsis, obstruction, pancreatitis, etc.) during the 5 years postsurgery.
SETTING: Global, multicenter.
METHODS: Using the TriNetX multi-institutional research database, we identified patients who underwent bariatric surgery, including 503 HIV-positive individuals who were prescribed antiretroviral therapy (ART) and 129,150 HIV-negative individuals. Propensity score matching was conducted to reduce confounding. Safety was assessed through time-to-event analyses for primary and secondary outcomes. Sensitivity analyses were performed to validate the findings.
RESULTS: No significant differences were observed in time-to-event analyses for mortality (P = .27) or inpatient admission (P = .46). Adverse health outcomes were comparable between cohorts, even in sensitivity analyses (all P > .05).
CONCLUSION: To our knowledge, this is the largest retrospective analysis to date examining bariatric surgery outcomes in HIV-positive patients prescribed ART. Results indicate that bariatric surgery is safe in this population, supporting its use as a viable intervention for obesity management among PLWH.
OBJECTIVES: This study aimed to compare the risk of all-cause mortality and inpatient admission between HIV-positive and HIV-negative patients undergoing bariatric surgery. Secondary aims included evaluating adverse events (sepsis, obstruction, pancreatitis, etc.) during the 5 years postsurgery.
SETTING: Global, multicenter.
METHODS: Using the TriNetX multi-institutional research database, we identified patients who underwent bariatric surgery, including 503 HIV-positive individuals who were prescribed antiretroviral therapy (ART) and 129,150 HIV-negative individuals. Propensity score matching was conducted to reduce confounding. Safety was assessed through time-to-event analyses for primary and secondary outcomes. Sensitivity analyses were performed to validate the findings.
RESULTS: No significant differences were observed in time-to-event analyses for mortality (P = .27) or inpatient admission (P = .46). Adverse health outcomes were comparable between cohorts, even in sensitivity analyses (all P > .05).
CONCLUSION: To our knowledge, this is the largest retrospective analysis to date examining bariatric surgery outcomes in HIV-positive patients prescribed ART. Results indicate that bariatric surgery is safe in this population, supporting its use as a viable intervention for obesity management among PLWH.