AIDS research and human retroviruses · 2025
Adverse Lipid Profiles and Increased Cardiovascular Risks in People with HAM/TSP.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Novaes Ana Flávia, Ferreira Qesya Rodrigues, Nascimento Jéssica Oliveira de Souza, Silva Roberta Muniz Luz, Moura Matheus Nascimento, Cruz Ariana Leal Borges da, Fernandes Larissa Alves, Umeda Arthur Shigueru, Santos João Pedro de Melo de Freitas, Aline Cristina Andrade Mota-Miranda, Tanajura Davi, Barreto Fernanda Khouri
Аннотация
The human T-lymphotropic virus 1 (HTLV-1) affects millions globally, notably in Brazil. The classical neurological presentation of this infection is HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). There is limited information on its association with lipid disorders and cardiovascular risks. Here, we compare the lipid profile of 30 people with HTLV-1 and HAM/TSP to 73 people with HTLV-1 without evidence of HAM/TSP from a Brazilian reference center between July 2021 and September 2023. People with HAM/TSP had lower levels of high-density lipoprotein and higher levels of low-density lipoprotein (LDL) and total cholesterol than people without HAM/TSP. In addition, people with HAM/TSP had a sixfold risk increase for elevated LDL. Therefore, patients with HAM/TSP show an adverse lipid profile, indicating higher dyslipidemia and cardiovascular risks. Regular lipid monitoring in this group is recommended.