Ophthalmic surgery, lasers & imaging retina · 2026
Partial Fluid-Air Exchange Enhances Submacular Injection of Retinal Sheets.
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Baldwin Grace, Akita Yukari, Manabe Koichiro, Kamei Tatsuya, Kuwahara Atsushi, Bleicher Isaac, Vavvas Demetrios G, Miller John B
Аннотация
BACKGROUND AND OBJECTIVE: Subretinal therapeutics represent a growing area of research with diverse clinical applications. Inadvertent reflux of therapeutic into the vitreous after delivery represents a surgical challenge that leads to therapeutic loss. This study sought to evaluate a modified technique utilizing partial fluid-air exchange (pFAX) to reduce reflux.
MATERIALS AND METHODS: This single-center study included 18 eyes of nine live pigs. Human iPSC-derived retinal sheets (Sumitomo Pharma) were injected into the subretinal space utilizing pFAX.
RESULTS: Retinal sheets were successfully delivered in all eyes. Incorporating pFAX reduced intraocular turbulence and reflux by maintaining (1) stable intraocular pressure, (2) self-sealing wound closure, and (3) subretinal bleb stability. When improper delivery or reflux of sheets did occur, reaspiration and reinjection was much easier with pFAX than with a fluid-filled eye.
CONCLUSION: Incorporating pFAX reduced reflux during subretinal injection of retinal sheets. This technique may enhance current and future applications of subretinal surgery.
MATERIALS AND METHODS: This single-center study included 18 eyes of nine live pigs. Human iPSC-derived retinal sheets (Sumitomo Pharma) were injected into the subretinal space utilizing pFAX.
RESULTS: Retinal sheets were successfully delivered in all eyes. Incorporating pFAX reduced intraocular turbulence and reflux by maintaining (1) stable intraocular pressure, (2) self-sealing wound closure, and (3) subretinal bleb stability. When improper delivery or reflux of sheets did occur, reaspiration and reinjection was much easier with pFAX than with a fluid-filled eye.
CONCLUSION: Incorporating pFAX reduced reflux during subretinal injection of retinal sheets. This technique may enhance current and future applications of subretinal surgery.