Frontiers in medicine · 2026
Global research trends and hotspots in the pathophysiology, imaging and therapy of type 3 macular neovascularization (MNV3) in age-related macular degeneration (AMD).
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Li Ye, Fu Xiangyu, Huang Ling, Xiao Lirong, Chen Danian
Аннотация
BACKGROUND: To provide an overview of the research hotspots and directions of type 3 macular neovascularization (MNV3) in age-related macular degeneration by bibliometric analysis.
METHODS: Publications related to MNV3 were retrieved from two databases, the Science Citation Index-Expanded database of the Web of Science Core Collection (WoSCC) and PubMed. CiteSpace was utilized to analyze country distribution, keyword bursts, and co-cited references. VOSviewer was employed to identify collaborative authors and the keyword co-occurrence network.
RESULTS: A total of 564 publications were identified from 2001 to 2026. They were performed in 97 countries, with the United States leading the way. Kim JW is the most prolific author, while Yannuzzi LA is the most cited author. Investigative Ophthalmology & Visual Science has published the most papers. Retina-The Journal of Retinal and Vitreous Diseases is the most cited journal. In the keyword co-occurrence network, apart from terms related to MNV3, "ranibizumab," "photodynamic therapy" and "optical coherence tomography" are high-frequency keywords, while terms such as "artificial intelligence," "biomarker," and "microglia" have emerged as more recent research hotspots. Research topics can be categorized into four major clusters: pathogenesis, imaging, therapy, clinical prognosis and long-term management. Meanwhile, highly cited co-cited articles successively addressed risk stratification, early identification, imaging evaluation, and standardized therapeutic regimens of MNV3, providing important references for clinical practice.
CONCLUSION: This bibliometric analysis elucidates research hotspots and directions in MNV3 across pathophysiology, imaging, and therapy, and outlines the dynamic development of research in this field.
METHODS: Publications related to MNV3 were retrieved from two databases, the Science Citation Index-Expanded database of the Web of Science Core Collection (WoSCC) and PubMed. CiteSpace was utilized to analyze country distribution, keyword bursts, and co-cited references. VOSviewer was employed to identify collaborative authors and the keyword co-occurrence network.
RESULTS: A total of 564 publications were identified from 2001 to 2026. They were performed in 97 countries, with the United States leading the way. Kim JW is the most prolific author, while Yannuzzi LA is the most cited author. Investigative Ophthalmology & Visual Science has published the most papers. Retina-The Journal of Retinal and Vitreous Diseases is the most cited journal. In the keyword co-occurrence network, apart from terms related to MNV3, "ranibizumab," "photodynamic therapy" and "optical coherence tomography" are high-frequency keywords, while terms such as "artificial intelligence," "biomarker," and "microglia" have emerged as more recent research hotspots. Research topics can be categorized into four major clusters: pathogenesis, imaging, therapy, clinical prognosis and long-term management. Meanwhile, highly cited co-cited articles successively addressed risk stratification, early identification, imaging evaluation, and standardized therapeutic regimens of MNV3, providing important references for clinical practice.
CONCLUSION: This bibliometric analysis elucidates research hotspots and directions in MNV3 across pathophysiology, imaging, and therapy, and outlines the dynamic development of research in this field.