Медицинская библиотека · Contraception · 2017

Residual hormone levels in used contraceptive rings as a measurement of adherence to vaginal ring use.

Haaland Richard E, Holder Angela, Evans-Strickfaden Tammy, Nyagol Beatrice, Makanga Mumbi, Oyaro Boaz, Humwa Felix, Williams Tiffany, McLellan-Lemal Eleanor, Desai Mitesh, Huey Michael J

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Аннотация

OBJECTIVE

This study sought to measure residual contraceptive hormone levels in vaginal rings as an adherence marker for monitoring product use in clinical trials.

STUDY

DESIGN

Residual etonogestrel and ethinyl estradiol levels from used NuvaRings® of 26 self-reported adherent women enrolled in a clinical trial of vaginal ring acceptability were compared to those from 16 women who used NuvaRing® as their contraceptive choice.

RESULTS

Twenty-one (81%) clinical trial rings had contraceptive hormone levels within the range of those used as a contraceptive choice. Five returned rings had unused or discordant levels of residual contraceptive hormones.

CONCLUSION

Residual vaginal ring drug levels could help assess adherence in clinical trials.

Для цитирования: Haaland Richard E, Holder Angela, Evans-Strickfaden Tammy, Nyagol Beatrice, Makanga Mumbi, Oyaro Boaz, Humwa Felix, Williams Tiffany, McLellan-Lemal Eleanor, Desai Mitesh, Huey Michael J. Residual hormone levels in used contraceptive rings as a measurement of adherence to vaginal ring use.. Contraception. 2017. DOI: 10.1016/j.contraception.2017.03.011.

Предметные рубрики MeSH

Administration, Intravaginal Clinical Trials as Topic Contraceptive Agents, Female Contraceptive Devices, Female Desogestrel Drug Combinations Ethinyl Estradiol Female Humans Kenya Patient Compliance United States

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