Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology · 2010
[The processes of cell renewal in H. pylori-associated chronic atrophic gastritis].
СтатьяНазвание и аннотация: Оригинал на русском
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Pasechnikov V D, Balabekov A V, Churkov S Z
Аннотация
OBJECTIVES: To evaluate the expression of Ki-67 protein in stomach mucosa in H. pylori-associated chronic atrophic gastritis according to the stage of atrophy.
MATERIALS AND METHODS: The immunohistochemical and histological study of gastric mucosal biopsies from dyspeptic patients was performed. The new international system of gastric musocal atrophy staging (OLGA) was used.
RESULTS: The rates of cellular proliferation increase along the rising of the stage of stomach mucosal atrophy in Hpylori-associated chronic atrophic gastritis.
CONCLUSIONS: In H. pylori-associated chronic atrophic gastritis, the acceleration of the cellular renewal was revealed, proportional to a stage of gastric mucosal atrophy that implies the increase of risk of development of precancerous changes.
MATERIALS AND METHODS: The immunohistochemical and histological study of gastric mucosal biopsies from dyspeptic patients was performed. The new international system of gastric musocal atrophy staging (OLGA) was used.
RESULTS: The rates of cellular proliferation increase along the rising of the stage of stomach mucosal atrophy in Hpylori-associated chronic atrophic gastritis.
CONCLUSIONS: In H. pylori-associated chronic atrophic gastritis, the acceleration of the cellular renewal was revealed, proportional to a stage of gastric mucosal atrophy that implies the increase of risk of development of precancerous changes.