[Genetic regulation and phenotype of inflammation in Helicobacter pylori infection].

The problem of the relationships between the macro- and microorganism in Helicobacter pylori infection is discussed in the context of the genetic regulation of inflammation. The leading role of host genetic polymorphism in maintaining an inflammatory response in the absence of the infectious organism is demonstrated, by using previous Helicobacter gastritis as an example. The combinations of polymorphisms of two genes IL-1beta-511T/IL-1RN . 2 and IL-1beta-31T/IL-1RN . 2, which provides an inflammation phenotype associated with the risk of impaired cell renewal and gastric mucosal atrophy, have been identified. The promising use of the phenotype of chronic atrophic gastritis in the present classifications as a prognostic category of gastric cancer is assessed.