G Protein-Coupled Receptor Signaling in CNS (Re)Myelination.

Loss of function in oligodendroglial cells is a pathological hallmark of demyelinating and neurodegenerative diseases. A significant pool of oligodendrocyte precursor cells is maintained in the adult brain following developmental myelination. This population of cells provides plasticity to the myelin network that is crucial for healthy brain function and facilitates myelin repair following demyelination. G protein-coupled receptors (GPCRs) represent a major target class in the druggable genome and are widely expressed in oligodendroglia. Targeting GPCRs involved in remyelination presents a tractable approach for the development of disease-modifying medicines. Despite this, the functional outcomes of GPCR modulation in oligodendroglia remain to be deeply explored, which has hindered the development of remyelinating therapies.