Internal medicine (Tokyo, Japan) · 2015
Identifying the Cause of the "Saturation Gap": Two Cases of Dapsone-induced Methemoglobinemia.
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Furuta Kenjiro, Ikeo Satoshi, Takaiwa Takuya, Ikeda Satoshi, Nishiyama Akihiro, Yokoyama Toshihide, Ito Akihiro, Tokioka Fumiaki, Tanaka Maki, Yoshioka Hiroshige, Tachibana Hiromasa, Arita Machiko, Hashimoto Toru, Ishida Tadashi
Аннотация
Diaphenylsulfone (DDS: Dapsone) is used for Pneumocystis pneumonia (PCP) prophylaxis, and methemoglobinemia has rarely been reported as a side effect of DDS. We herein report two cases of DDS-related methemoglobinemia in an 81-year-old man with organizing pneumonia and an 84-year-old woman with eosinophilic pneumonia under treatment with prednisolone. Both patients initially received trimethoprim/sulfamethoxazole for PCP prophylaxis and were switched to DDS due to side effects and subsequently exhibited a clinically unexplainable decrease in SpO2. Methemoglobinemia was diagnosed based on the findings of arterial blood gas analyses. In both cases, the methemoglobinemia improved after discontinuing DDS.