Latent Tuberculosis Infection Management in Solid Organ Transplantation Recipients: A National Snapshot.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
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Alpaydın Aylin Özgen, Turunç Tuba Yeter, Avkan-Oğuz Vildan, Öner-Eyüboğlu Füsun, Tükenmez-Tigen Elif, Hasanoğlu İmran, Aydın Güle, Tezer-Tekçe Yasemin, Şenbayrak Seniha, Kızılateş Filiz, Aypak Adalet Altunsoy, Toplu Sibel Altunışık, Ergen Pınar, Kurtaran Behice, Taşbakan Meltem Işıkgöz, Yıldırım Ayşegül, Yıldız Serkan, Çalışkan Kenan, Ayvazoğlu Ebru, Dulundu Ender, Şeref Parlak Ebru Şengül, Akdemir İrem, Kara Melih, Türkkan Sinan, Demir-Önder Kübra, Yenigün Ezgi, Turgut Aslı, Ecder Sabahat Alışır, Paydaş Saime, Yamazhan Tansu, Egeli Tufan, Özelsancak Rüya, Velioğlu Arzu, Kılıç Mehmet, Azap Alpay, Yekeler Erdal, Çakır Tuğrul, Bayındır Yaşar, Kanbay Asiye, Kuşcu Ferit, Memikoğlu Kemal Osman, Şen Nazan, Kabasakal Erhan, Ersöz Gülden
Аннотация
MATERIAL AND METHODS: Adult SOT recipients who underwent tuberculin skin test (TST) and/or interferon-gamma release test (IGRA) from 14 centers between 2015 and 2019 were included in the study. An induration of ≥5 mm on TST and/or probable/positive IGRA (QuantiFERON-TB) was considered positive for LTBI. Demographic features, LTBI screening and treatment, and pre-/post-transplant TB history were recorded from the electronic database of transplantation units across the country and pooled at a single center for a unified database.
RESULTS: TST and/or IGRA were performed in 766 (33.8%) of 2266 screened patients most of whom were kidney transplant recipients (n = 485, 63.4%). LTBI screening test was positive in 359 (46.9%) patients, and isoniazid was given to 203 (56.5%) patients. Of the patients treated for LTBI, 112 (55.2%) were registered in the national registry, and 82 (73.2%) completed the treatment. Tuberculosis developed in 6 (1.06%) of 563 patients who were not offered LTBI treatment.
CONCLUSION: We determined that overall, only one-third of SOT recipients in our country were evaluated in terms of TB risk, only 1 of the 2 SOT recipients with LTBI received treatment, and half were registered. Therefore, we want to emphasize the critical importance of pretransplant TB risk stratification and registration, guided by revised national guidelines.