PLOS global public health · 2023
Plasma CXCL8 and MCP-1 as surrogate plasma biomarkers of latent tuberculosis infection among household contacts-A cross-sectional study.
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Selvavinayagam Sivaprakasam T, Aswathy Bijulal, Yong Yean K, Frederick Asha, Murali Lakshmi, Kalaivani Vasudevan, Karishma Sree J, Rajeshkumar Manivannan, Anusree Adukkadukkam, Kannan Meganathan, Gopalan Natarajan, Vignesh Ramachandran, Murugesan Amudhan, Tan Hong Yien, Zhang Ying, Chandramathi Samudi, Sivasankaran Munusamy Ponnan, Balakrishnan Pachamuthu, Govindaraj Sakthivel, Byrareddy Siddappa N, Velu Vijayakumar, Larsson Marie, Shankar Esaki M, Raju Sivadoss
Аннотация
Early detection of latent tuberculosis infection (LTBI) is critical to TB elimination in the current WHO vision of End Tuberculosis Strategy. The study investigates whether detecting plasma cytokines could aid in diagnosing LTBI across household contacts (HHCs) positive for IGRA, HHCs negative for IGRA, and healthy controls. The plasma cytokines were measured using a commercial Bio-Plex Pro Human Cytokine 17-plex assay. Increased plasma CXCL8 and decreased MCP-1, TNF-α, and IFN-γ were associated with LTBI. Regression analysis showed that a combination of CXCL8 and MCP-1 increased the risk of LTBI among HHCs to 14-fold. Our study suggests that CXCL-8 and MCP-1 could serve as the surrogate biomarkers of LTBI, particularly in resource-limited settings. Further laboratory investigations are warranted before extrapolating CXCL8 and MCP-1 for their usefulness as surrogate biomarkers of LTBI in resource-limited settings.