Atencion primaria · 2026
[Long-term symptomatic follow-up of patients with Long COVID syndrome].
СтатьяНаблюдательное исследованиеАннотация на английскомНазвание и аннотация: Перевод пока не подготовлен
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Carrascosa Gil Andrés, Gabella Martín Miriam, Salazar Lozano María Del Camino, Tamayo Gómez Eduardo, Rico Feijoo Jesús, Álvarez de Santullano César Aldecoa
Аннотация
OBJECTIVE: The primary aim of the study was to investigate the long-term symptom progression of long COVID. The secondary objective was to assess whether any treatment had an impact on symptom evolution.
DESIGN: Longitudinal, prospective, observational, uncontrolled study.
SETTING: Internal Medicine Department, Río Hortega University Hospital (Valladolid).
PARTICIPANTS: 40 patients with long COVID (cases) and 40 volunteers (controls) of the same age and sex as the cases, who had experienced acute COVID-19 without developing long COVID.
MAIN MEASUREMENTS: Scales, indices, and questionnaires were sent by post to evaluate the main symptoms of long COVID. The following were assessed: fatigue (MFIS), emotional disorders (HADS), sleep disturbances (PSQI), cognitive impairments (MFE-30), dyspnea (mMRC), physical exercise (GPAQ), quality of life (SF-36), and pain (CPGS). The cases were reassessed after three years.
RESULTS: After three years, cases showed an improvement in dyspnea (mMRC), which decreased from 1.38 to 1.10 (p=0.014). Ten cases reported having followed aerobic and/or anaerobic physical exercise as treatment, and it was observed that their pain severity (CPGS) improved from 2.7 to 1.3 (p=0.039). In the remaining measurements, variations among cases did not reach statistical significance.
CONCLUSIONS: After three years of follow-up, patients with long COVID continued to have similar symptom scores to their initial assessments, and worse than those of the control group. Aerobic and/or anaerobic physical exercise may contribute to partially improving symptom evolution. .
DESIGN: Longitudinal, prospective, observational, uncontrolled study.
SETTING: Internal Medicine Department, Río Hortega University Hospital (Valladolid).
PARTICIPANTS: 40 patients with long COVID (cases) and 40 volunteers (controls) of the same age and sex as the cases, who had experienced acute COVID-19 without developing long COVID.
MAIN MEASUREMENTS: Scales, indices, and questionnaires were sent by post to evaluate the main symptoms of long COVID. The following were assessed: fatigue (MFIS), emotional disorders (HADS), sleep disturbances (PSQI), cognitive impairments (MFE-30), dyspnea (mMRC), physical exercise (GPAQ), quality of life (SF-36), and pain (CPGS). The cases were reassessed after three years.
RESULTS: After three years, cases showed an improvement in dyspnea (mMRC), which decreased from 1.38 to 1.10 (p=0.014). Ten cases reported having followed aerobic and/or anaerobic physical exercise as treatment, and it was observed that their pain severity (CPGS) improved from 2.7 to 1.3 (p=0.039). In the remaining measurements, variations among cases did not reach statistical significance.
CONCLUSIONS: After three years of follow-up, patients with long COVID continued to have similar symptom scores to their initial assessments, and worse than those of the control group. Aerobic and/or anaerobic physical exercise may contribute to partially improving symptom evolution. .