Hepatology research : the official journal of the Japan Society of Hepatology · 2026
Guidance for Liver Rehabilitation in Chronic Liver Disease.
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Terai Shuji, Kamimura Hiroteru, Hiasa Yoichi, Akuta Norio, Ishikawa Toru, Eguchi Yuichiro, Okubo Hironao, Kawaguchi Takumi, Kawanaka Miwa, Kanda Tatsuo, Korenaga Masaaki, Sakamori Ryotaro, Shimizu Masahito, Sumida Yoshio, Tateishi Ryosuke, Tanaka Atsushi, Tanaka Naoki, Tanaka Yasuo, Tahata Yuki, Nakai Masato, Namisaki Tadashi, Nishimura Takashi, Hiraoka Atsushi, Matsui Takeshi, Mori Nami, Moriya Akio, Takehara Tetsuo
Аннотация
In April 2023, the Japan Society of Hepatology published its official guidelines on liver rehabilitation for chronic liver disease. In this article, we summarize the current evidence on the role of liver rehabilitation in slowing the progression of chronic liver disease, particularly metabolic dysfunction-associated steatotic liver disease (MASLD), liver cirrhosis, and hepatocellular carcinoma (HCC). Specifically, we outline the following: (1) the definition of liver rehabilitation and its target population; (2) exercise therapy in liver rehabilitation according to disease state; (3) considerations for patients with complications; (4) nutritional therapy in liver rehabilitation; and (5) potential economic benefits. Liver rehabilitation represents a novel therapeutic approach for patients with chronic liver disease, and this guidance aims to promote high-quality clinical research and strengthen the evidence base for its application.