Neurologia i neurochirurgia polska · 2026
Glymphatic system activity in functional movement disorder - a link to widespread pain.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Nepožitek Jiří, Mareček Stanislav, Sojka Petr, Nováková Lucia, Voženílek David, Serranová Tereza
Аннотация
AIM OF THE STUDY: The study aimed to evaluate glymphatic function in functional movement disorder (FMD) and examine its clinical correlates.
CLINICAL RATIONALE FOR THE STUDY: The glymphatic system plays a key role in brain homeostasis by facilitating perivascular clearance of interstitial fluid and metabolic waste, particularly during sleep. The diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) index provides a non-invasive magnetic resonance imaging-derived (MRI-derived) proxy of glymphatic system activity. The involvement of the glymphatic system in FMD is unknown.
MATERIAL AND METHODS: Fifty-four patients with FMD and 52 healthy controls underwent 3T MRI, including DTI. Glymphatic activity was quantified using the DTI-ALPS index. Group differences were assessed with t-tests and analyses of covariance (ANCOVA), controlling for age, gender, and medication status. Associations with clinical measures, including pain intensity - Visual Analog Scale (VAS), Widespread Pain Index (WPI) - fatigue, mood, and motor severity, were examined using Pearson and partial correlations.
RESULTS: DTI-ALPS indices did not differ between patients and controls. Compared with healthy controls, patients with FMD showed significantly higher levels of depressive symptoms, fatigue, pain, and somatic symptom burden (all p < 0.001). Among clinical measures, only WPI showed significant negative correlations with ALPS indices (average ALPS index partial r = -0.42; p = 0.004; ALPS index of the right hemisphere partial r = -0.39; p = 0.008; ALPS index of the left hemisphere partial r = -0.38; p = = 0.011), whereas VAS and other clinical symptoms did not.
CONCLUSIONS AND CLINICAL IMPLICATIONS: Glymphatic function appears preserved in FMD. In line with previous reports, we found an association with widespread pain experience, suggesting that glymphatic dysfunction could play a role in symptom perception rather than disorder-specific pathology.
CLINICAL RATIONALE FOR THE STUDY: The glymphatic system plays a key role in brain homeostasis by facilitating perivascular clearance of interstitial fluid and metabolic waste, particularly during sleep. The diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) index provides a non-invasive magnetic resonance imaging-derived (MRI-derived) proxy of glymphatic system activity. The involvement of the glymphatic system in FMD is unknown.
MATERIAL AND METHODS: Fifty-four patients with FMD and 52 healthy controls underwent 3T MRI, including DTI. Glymphatic activity was quantified using the DTI-ALPS index. Group differences were assessed with t-tests and analyses of covariance (ANCOVA), controlling for age, gender, and medication status. Associations with clinical measures, including pain intensity - Visual Analog Scale (VAS), Widespread Pain Index (WPI) - fatigue, mood, and motor severity, were examined using Pearson and partial correlations.
RESULTS: DTI-ALPS indices did not differ between patients and controls. Compared with healthy controls, patients with FMD showed significantly higher levels of depressive symptoms, fatigue, pain, and somatic symptom burden (all p < 0.001). Among clinical measures, only WPI showed significant negative correlations with ALPS indices (average ALPS index partial r = -0.42; p = 0.004; ALPS index of the right hemisphere partial r = -0.39; p = 0.008; ALPS index of the left hemisphere partial r = -0.38; p = = 0.011), whereas VAS and other clinical symptoms did not.
CONCLUSIONS AND CLINICAL IMPLICATIONS: Glymphatic function appears preserved in FMD. In line with previous reports, we found an association with widespread pain experience, suggesting that glymphatic dysfunction could play a role in symptom perception rather than disorder-specific pathology.