Frontiers in cardiovascular medicine · 2026
The association between time-weighted cumulative life's essential 8 and aortic valve calcification.
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Gui Man, Wu Shouling, Wang Tonghaoyu, Qi Yihao, Huo Zhenyu, Gao Ying, Zhang Haiyan, Han Ying, Deng Jialing, Dong Jing, Wang Taiying, Chen Shuohua, Xing Fengmei
Аннотация
OBJECTIVE: To examine the association between the time-weighted cumulative Life's Essential 8 (TWC-LE8) score and aortic valve calcification (AVC).
METHODS: This analysis included 15,321 adults (mean age, 63.79 years; 76.44% men) from the Kailuan cohort who completed four health examinations between 2006 and 2012 and subsequently underwent standardized echocardiography. The TWC-LE8 score (range, 0-100) was used to classify cardiovascular health (CVH) as low (<50), moderate (50-79), or high (≥80). Multivariable logistic regression was used to estimate odds ratios (ORs) for AVC across CVH categories, and restricted cubic spline models were applied to assess the dose-response relationship.
RESULTS: A total of 2,894 AVC cases were identified. Compared with low CVH, moderate CVH was associated with lower odds of AVC (OR = 0.53, 95% CI: 0.47-0.61), and high CVH was associated with even lower odds of AVC (OR = 0.25, 95% CI: 0.15-0.40). A linear inverse association between TWC-LE8 score and AVC was observed (P for trend < 0.001). Age-stratified analyses showed significant heterogeneity. Among participants aged ≥55 years, high CVH was associated with 74% lower odds of AVC (OR = 0.26, 95% CI: 0.15-0.45), whereas no significant association was observed among those aged <55 years.
CONCLUSION: Higher cumulative LE8 scores were strongly associated with lower odds of AVC, particularly among older adults. These findings support an inverse association between long-term cardiovascular health and AVC.
METHODS: This analysis included 15,321 adults (mean age, 63.79 years; 76.44% men) from the Kailuan cohort who completed four health examinations between 2006 and 2012 and subsequently underwent standardized echocardiography. The TWC-LE8 score (range, 0-100) was used to classify cardiovascular health (CVH) as low (<50), moderate (50-79), or high (≥80). Multivariable logistic regression was used to estimate odds ratios (ORs) for AVC across CVH categories, and restricted cubic spline models were applied to assess the dose-response relationship.
RESULTS: A total of 2,894 AVC cases were identified. Compared with low CVH, moderate CVH was associated with lower odds of AVC (OR = 0.53, 95% CI: 0.47-0.61), and high CVH was associated with even lower odds of AVC (OR = 0.25, 95% CI: 0.15-0.40). A linear inverse association between TWC-LE8 score and AVC was observed (P for trend < 0.001). Age-stratified analyses showed significant heterogeneity. Among participants aged ≥55 years, high CVH was associated with 74% lower odds of AVC (OR = 0.26, 95% CI: 0.15-0.45), whereas no significant association was observed among those aged <55 years.
CONCLUSION: Higher cumulative LE8 scores were strongly associated with lower odds of AVC, particularly among older adults. These findings support an inverse association between long-term cardiovascular health and AVC.