Frontiers in medicine · 2025
The relationship between initial vitamin D levels and in vitro fertilization (IVF) outcomes in PCOS patients: a systematic review.
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Octavia Leony, Andhika Panjarwanto Dwi, Nabila Putri, Geany Putri Lenggo, Javier R Mohamad, Rahman Aldo Aulia, Yora Vallexa Septina, Sutanto Lucky, Tandayu Arthur Peter, Varsha Srigita, Solichin Sofyan
Аннотация
BACKGROUND: Polycystic Ovary Syndrome (PCOS) is a common endocrine disorder affecting reproductive-age women and is often associated with infertility challenges. Recent studies suggest that vitamin D levels play a significant role in reproductive outcomes, particularly in PCOS patients undergoing in vitro fertilization (IVF).
METHODS: A systematic review was conducted following PRISMA guidelines. Studies published between 2014 and 2024 were analyzed, focusing on the impact of pre-treatment vitamin D levels on IVF outcomes such as fertilization rates, implantation rates, clinical pregnancy, and live birth rates. Only studies on PCOS-related infertility were included, while non-PCOS infertility cases were excluded.
RESULT: The review examined 59 studies, highlighting variations in outcomes based on study design and populations. Evidence generally supports the hypothesis that adequate vitamin D levels are associated with improved IVF success, though inconsistencies remain. Further research is recommended to standardize supplementation protocols and better understand vitamin D's biological mechanisms in reproductive health.
CONCLUSION: The relationship between initial vitamin D levels and in vitro fertilization (IVF) outcomes in women with polycystic ovary syndrome (PCOS) suggests that vitamin D plays a crucial role in enhancing IVF success, although the findings remain somewhat inconsistent. Research generally points to a positive correlation between higher baseline vitamin D levels and improved reproductive results, including increased live birth rates, pregnancy rates, and better ovarian responses during IVF treatments.
SYSTEMATIC REVIEW REGISTRATION: CRD42024622381, https://www.crd.york.ac.uk/PROSPERO/view/CRD42024622381.
METHODS: A systematic review was conducted following PRISMA guidelines. Studies published between 2014 and 2024 were analyzed, focusing on the impact of pre-treatment vitamin D levels on IVF outcomes such as fertilization rates, implantation rates, clinical pregnancy, and live birth rates. Only studies on PCOS-related infertility were included, while non-PCOS infertility cases were excluded.
RESULT: The review examined 59 studies, highlighting variations in outcomes based on study design and populations. Evidence generally supports the hypothesis that adequate vitamin D levels are associated with improved IVF success, though inconsistencies remain. Further research is recommended to standardize supplementation protocols and better understand vitamin D's biological mechanisms in reproductive health.
CONCLUSION: The relationship between initial vitamin D levels and in vitro fertilization (IVF) outcomes in women with polycystic ovary syndrome (PCOS) suggests that vitamin D plays a crucial role in enhancing IVF success, although the findings remain somewhat inconsistent. Research generally points to a positive correlation between higher baseline vitamin D levels and improved reproductive results, including increased live birth rates, pregnancy rates, and better ovarian responses during IVF treatments.
SYSTEMATIC REVIEW REGISTRATION: CRD42024622381, https://www.crd.york.ac.uk/PROSPERO/view/CRD42024622381.