Journal of Taibah University Medical Sciences · 2025
Factors affecting marriage decisions among couples with sickle cell or beta-thalassemia traits.
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Badedi Mohammed, Muidh Abdulrahman, Alsayed Mannaa, Darraj Hussain, Shubaili Ali, Darraj Abdulaziz, Hobani Yahya, Ahmadini Musa, Hakami Ibrahim, Gharawi Nabeel, Hakami Mohammed, Shrwani Khalid, Malhan Nhari, Mokali Asma, Abdaly Ahmed
Аннотация
OBJECTIVE: This study assessed the prevalence of marriage among genetically incompatible couples at risk of having children with either sickle cell disease (SCD) or beta-thalassemia (β-thalassemia) in Jazan province, KSA, and the factors influencing these couples' decisions to marry.
METHODS: An analytical cross-sectional research design was used. From the National Health Premarital Screening System database, couples whose premarital screening tests indicated genetic incompatibility and a risk of having children with either SCD or β-thalassemia were randomly selected, with a sample size of 386 couples.
RESULTS: The prevalence of risky marriages that might result in children with SCD or β-thalassemia was 60.4 %. Marriage was more favored among participants who already were married, divorced, or widowed, or who had children during the screening period, than among unmarried participants (P = 0.006). Couples with good knowledge and awareness of the risks of SCD to children's lives decided not to marry (P = 0.001). Furthermore, couples who attended all relevant counseling sessions were more likely to decide not to marry than those who attended only one counseling session (P = 0.001). Despite the positive effects of these counseling sessions, many social, cultural, and religious factors, most prominently religion (70.8 %), influenced these couples' decisions to marry and accept the possibility of having a child with SCD or β-thalassemia.
CONCLUSION: Given the high prevalence of SCD and at-risk marriages in the Jazan region, in vitro fertilization and pre-implantation genetic testing services are recommended.
METHODS: An analytical cross-sectional research design was used. From the National Health Premarital Screening System database, couples whose premarital screening tests indicated genetic incompatibility and a risk of having children with either SCD or β-thalassemia were randomly selected, with a sample size of 386 couples.
RESULTS: The prevalence of risky marriages that might result in children with SCD or β-thalassemia was 60.4 %. Marriage was more favored among participants who already were married, divorced, or widowed, or who had children during the screening period, than among unmarried participants (P = 0.006). Couples with good knowledge and awareness of the risks of SCD to children's lives decided not to marry (P = 0.001). Furthermore, couples who attended all relevant counseling sessions were more likely to decide not to marry than those who attended only one counseling session (P = 0.001). Despite the positive effects of these counseling sessions, many social, cultural, and religious factors, most prominently religion (70.8 %), influenced these couples' decisions to marry and accept the possibility of having a child with SCD or β-thalassemia.
CONCLUSION: Given the high prevalence of SCD and at-risk marriages in the Jazan region, in vitro fertilization and pre-implantation genetic testing services are recommended.