International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025
Influence of assisted reproductive technology procedures on the fatty acid status and their association with birth outcome.
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Kapare Aishwarya, Yadav Himanshi, Randhir Karuna, Gupte Sanjay, Sundrani Deepali, Joshi Sadhana
Аннотация
OBJECTIVE: This study examines the influence of assisted reproductive technology (ART) procedures on maternal and placental fatty acid status and their correlation with placental weight and birth outcome.
METHODS: Pregnant women were recruited at Gupte Hospital, Pune, India and grouped as those with natural pregnancy (non-ART) (n = 93) and those who underwent ART procedures (ART) (n = 64). Fatty acids were analyzed using gas chromatography. Group comparisons were performed using an independent t-test. Partial correlation test controlling for maternal age, body mass index, gestational age and baby sex was used for association of fatty acid status with placental weight and birth outcome.
RESULTS: Maternal and placental total omega-3 fatty acids were significantly lower (P = 0.023 and P = 0.050 respectively) and the omega-6: omega-3 fatty acid ratio was higher (P = 0.041 and P = 0.050, respectively) in ART pregnancies in comparison to natural pregnancies. The ART group, further categorized as in vitro fertilization (IVF) and intrauterine insemination (IUI), showed lower maternal dihomo-gamma-linolenic acid (DGLA) (P = 0.033) and placental docosapentaenoic acid (DPA) levels only in the IVF group (0.011) and not in the IUI group in comparison to the non-ART group. Placental arachidonic acid (AA), omega-6 and total polyunsaturated fatty acid (PUFA) levels were negatively associated, whereas placental monounsaturated fatty acid (MUFA) levels were positively associated with placental weight (P < 0.001 for others and P = 0.008 for MUFA) and birth weight (P < 0.001, P = 0.001, P = 0.004, P = 0.005, respectively).
CONCLUSION: ART procedures, particularly IVF, are associated with disturbed maternal and placental fatty acid metabolism that influences placental weight and, thereby, birth outcome.
METHODS: Pregnant women were recruited at Gupte Hospital, Pune, India and grouped as those with natural pregnancy (non-ART) (n = 93) and those who underwent ART procedures (ART) (n = 64). Fatty acids were analyzed using gas chromatography. Group comparisons were performed using an independent t-test. Partial correlation test controlling for maternal age, body mass index, gestational age and baby sex was used for association of fatty acid status with placental weight and birth outcome.
RESULTS: Maternal and placental total omega-3 fatty acids were significantly lower (P = 0.023 and P = 0.050 respectively) and the omega-6: omega-3 fatty acid ratio was higher (P = 0.041 and P = 0.050, respectively) in ART pregnancies in comparison to natural pregnancies. The ART group, further categorized as in vitro fertilization (IVF) and intrauterine insemination (IUI), showed lower maternal dihomo-gamma-linolenic acid (DGLA) (P = 0.033) and placental docosapentaenoic acid (DPA) levels only in the IVF group (0.011) and not in the IUI group in comparison to the non-ART group. Placental arachidonic acid (AA), omega-6 and total polyunsaturated fatty acid (PUFA) levels were negatively associated, whereas placental monounsaturated fatty acid (MUFA) levels were positively associated with placental weight (P < 0.001 for others and P = 0.008 for MUFA) and birth weight (P < 0.001, P = 0.001, P = 0.004, P = 0.005, respectively).
CONCLUSION: ART procedures, particularly IVF, are associated with disturbed maternal and placental fatty acid metabolism that influences placental weight and, thereby, birth outcome.