[The formation of atherosclerotic prodromes in risk-group adolescents at stages in their sexual maturation].

240 adolescents with primary arterial hypertension and 118 youngsters from families with aggravated heredity in respect of ischemic heart disease were studied for lipidic spectrum of blood, system of prostanoides and some hemodynamic indexes during the puberty stages. It has been found out that adolescents of risk groups for atherosclerosis develop metabolic disturbances presented as atherogenic dyslipoproteinemias and thrombogenic balance of prostanoides. A particular feature of the above disturbances is their apparent stability, they are responsible for structural alterations in the vascular wall presented as its thickening and loss of elasticity. This suggests that not only metabolic basis of atherosclerosis might be formed during the pubescence stages but structural one as well.