Journal of investigative surgery : the official journal of the Academy of Surgical Research · 2017
Apoptosis in Primary Hyperparathyroidism.
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Segiet Oliwia Anna, Mielańczyk Łukasz, Piecuch Adam, Michalski Marek, Tyczyński Szczepan, Brzozowa-Zasada Marlena, Deska Mariusz, Wojnicz Romuald
Аннотация
Primary hyperparathyroidism (PHPT) is defined by inappropriate elevation of parathormone, caused by parathyroid hyperplasia, also known as multi-gland disease (MGD), parathyroid adenoma (PA), or parathyroid carcinoma (PC). Although several studies have already been conducted, there is a lack of a definite diagnostic marker, which could unambiguously distinguish MGD from PA or PC. The accurate and prompt diagnosis has the key meaning for effective treatment and follow-up. This review paper presents the role of apoptosis in PHPT. The comparison of the expression of Fas, TRAIL, BCL-2 family members, p53 in MGD, PA, and PC, among others, was described. The expression of described factors varies among proliferative lesions of parathyroid gland; therefore, these could serve as additional markers to assist in the diagnosis.