Health science reports · 2026
Hypertriglyceridemia‑Induced Acute Pancreatitis Compared With Non-Hypertriglyceridemia Acute Pancreatitis: A Retrospective Case-Control Study.
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Farhangiyan Zahra, Moradi Leila, Vaziri Mehrdad, Lak Elena, Zaman Ferdos, Mohammadi Shooka
Аннотация
BACKGROUND AND AIMS: Hypertriglyceridemia-induced acute pancreatitis (HTGAP) is a distinct clinical subtype of acute pancreatitis (AP), but comparative data remain limited. This study aimed to compare risk factors, disease severity, and clinical outcomes between patients with HTGAP and non-HTGAP.
METHODS: A single-center retrospective case-control study was conducted using medical records of patients diagnosed with AP who were admitted to Imam Hospital (Ahvaz, Iran) between May 2020 and May 2025. Patients were categorized into HTGAP (n = 150) and non-HTGAP (n = 150) groups. Demographic data, severity scores, clinical complications, and length of hospital stay were compared between the two groups.
RESULTS: HTGAP was associated with significantly higher rates of complications, including acute respiratory distress syndrome, acute peripancreatic fluid collection, sepsis, acute necrotizing pancreatitis, pancreatic pseudocyst, walled-off or infected pancreatic necrosis, and renal failure (p < 0.05). HTGAP patients were younger and had higher body mass index than non-HTGAP patients (p < 0.001). They also had significantly higher mean Ranson (3.18 vs. 2.53), 24-h Acute Physiology, Chronic Health Evaluation II (APACHE II) (9.78 vs. 6.88), and modified computed tomography severity index (MCTSI) scores (7.08 vs. 4.54), as well as longer hospital stays (9.44 vs. 5.00 days), compared with non-HTGAP patients (p < 0.001). No in-hospital mortality occurred.
CONCLUSION: HTGAP was associated with a more severe clinical profile and higher complication rates than non-HTGAP, highlighting the need for early recognition and careful management. Interpretation of these findings is limited by the retrospective single-center design and absence of multivariable adjustment.
METHODS: A single-center retrospective case-control study was conducted using medical records of patients diagnosed with AP who were admitted to Imam Hospital (Ahvaz, Iran) between May 2020 and May 2025. Patients were categorized into HTGAP (n = 150) and non-HTGAP (n = 150) groups. Demographic data, severity scores, clinical complications, and length of hospital stay were compared between the two groups.
RESULTS: HTGAP was associated with significantly higher rates of complications, including acute respiratory distress syndrome, acute peripancreatic fluid collection, sepsis, acute necrotizing pancreatitis, pancreatic pseudocyst, walled-off or infected pancreatic necrosis, and renal failure (p < 0.05). HTGAP patients were younger and had higher body mass index than non-HTGAP patients (p < 0.001). They also had significantly higher mean Ranson (3.18 vs. 2.53), 24-h Acute Physiology, Chronic Health Evaluation II (APACHE II) (9.78 vs. 6.88), and modified computed tomography severity index (MCTSI) scores (7.08 vs. 4.54), as well as longer hospital stays (9.44 vs. 5.00 days), compared with non-HTGAP patients (p < 0.001). No in-hospital mortality occurred.
CONCLUSION: HTGAP was associated with a more severe clinical profile and higher complication rates than non-HTGAP, highlighting the need for early recognition and careful management. Interpretation of these findings is limited by the retrospective single-center design and absence of multivariable adjustment.