[Recent advances in novel biomarkers for severity assessment and prognostic prediction in severe acute pancreatitis].

Severe acute pancreatitis (SAP) is a critical condition frequently encountered in the intensive care unit (ICU), with high incidence, mortality, and healthcare costs. The complexity and difficulty in predicting its severity and prognosis stem from multiple etiologies, dynamic disease progression, multi-organ dysfunction, and variations in clinical management. Traditional scoring systems and indicators often lack timeliness and adequate predictive performance. Therefore, there is an urgent need for novel, reliable, and easily measurable biomarkers to seize the valuable "window of opportunity" and to promote a shift in clinical management from passive response to proactive intervention. This review summarizes recent advances in biomarker research related to the severity and prognosis of SAP, aiming to provide new perspectives for the development of predictive tools and models.