Pathogens (Basel, Switzerland) · 2026
Increasing Case Numbers and Earlier Age at Diagnosis of Alveolar Echinococcosis: Insights from a 13-Year Retrospective Swiss Study.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод в очереди
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Weikert Lasse, Kasmi Sophie, Schneider Michael, Faouzi Mohamed, Schmidt Kobbe Sabine, Sempoux Christine, Cavassini Matthias, Gauthiez Emeline, Uldry Emilie, Fraga Montserrat
Аннотация
INTRODUCTION: Alveolar echinococcosis (AE) is a rare zoonotic infection caused by Echinococcus multilocularis. In recent years, the number of reported cases has increased across Europe, including Switzerland.
METHODS: We conducted a retrospective observational study at Lausanne University Hospital (CHUV), including all AE cases diagnosed between 2010 and 2023 within the Departments of Gastroenterology and Hepatology, Visceral Surgery, and Infectious Diseases.
RESULTS: Eighty patients with AE were identified. Half of them were male. The mean annual incidence was 0.53 cases per 100,000 population (range, 0.14-0.85), with a statistically significant increase over time in the canton of Vaud (p = 0.037). The median age at diagnosis was 61.5 years, showing a significant downward trend during the study period. At diagnosis, 45 patients (56.3%) were asymptomatic, and 17 (21.3%) were immunosuppressed. Compared with immunocompetent patients, immunosuppressed individuals more often presented asymptomatically, had significantly smaller hepatic lesions, and were more frequently seronegative.
CONCLUSIONS: This study demonstrates evolving epidemiological patterns of AE in Switzerland, characterized by increasing incidence and a high proportion of asymptomatic cases. Immunosuppressed patients tended to present with milder disease. Our findings highlight the need for strengthened surveillance and support the ongoing efforts to establish a national AE registry.
METHODS: We conducted a retrospective observational study at Lausanne University Hospital (CHUV), including all AE cases diagnosed between 2010 and 2023 within the Departments of Gastroenterology and Hepatology, Visceral Surgery, and Infectious Diseases.
RESULTS: Eighty patients with AE were identified. Half of them were male. The mean annual incidence was 0.53 cases per 100,000 population (range, 0.14-0.85), with a statistically significant increase over time in the canton of Vaud (p = 0.037). The median age at diagnosis was 61.5 years, showing a significant downward trend during the study period. At diagnosis, 45 patients (56.3%) were asymptomatic, and 17 (21.3%) were immunosuppressed. Compared with immunocompetent patients, immunosuppressed individuals more often presented asymptomatically, had significantly smaller hepatic lesions, and were more frequently seronegative.
CONCLUSIONS: This study demonstrates evolving epidemiological patterns of AE in Switzerland, characterized by increasing incidence and a high proportion of asymptomatic cases. Immunosuppressed patients tended to present with milder disease. Our findings highlight the need for strengthened surveillance and support the ongoing efforts to establish a national AE registry.