American journal of ophthalmology case reports · 2022
Bilateral asymptomatic macular hypopigmentation in a young woman: multimodal imaging and pathogenetic hypothesis.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Fantaguzzi Federico, Zucchiatti Ilaria, Sacconi Riccardo, Bux Anna Valeria, Prascina Francesco, Bandello Francesco, Querques Giuseppe
Аннотация
PURPOSE: Macular retinal pigment epithelium (RPE) hypopigmentation is a recently described very rare condition and its pathogenesis is not completely understood. We report the case of a 23-year-old female who presented with bilateral whitish, oval-shaped foveal lesions and we speculated about the possible etiopathogenetic origin.
OBSERVATIONS: A 23-year-old female presented to our consideration for a routine ophthalmology visit. Visual acuity was 20/20 in both eyes. The fundus examination revealed a perifoveal choroidal nevus in the right eye and a bilateral yellowish, oval-shaped lesion centered on the fovea. Imaging tests (Spectral Domain-Optical Coherence Tomography, short wavelength and near-infrared autofluorescence) and functional tests (microperimetry and multifocal electroretinogram) were within normal limits, supporting the diagnosis of macular hypopigmentation without functional loss.
CONCLUSIONS: A complex dysregulation of both choroidal and RPE with melanin loss may be responsible for this condition.
OBSERVATIONS: A 23-year-old female presented to our consideration for a routine ophthalmology visit. Visual acuity was 20/20 in both eyes. The fundus examination revealed a perifoveal choroidal nevus in the right eye and a bilateral yellowish, oval-shaped lesion centered on the fovea. Imaging tests (Spectral Domain-Optical Coherence Tomography, short wavelength and near-infrared autofluorescence) and functional tests (microperimetry and multifocal electroretinogram) were within normal limits, supporting the diagnosis of macular hypopigmentation without functional loss.
CONCLUSIONS: A complex dysregulation of both choroidal and RPE with melanin loss may be responsible for this condition.