Arquivos brasileiros de oftalmologia · 2006
[Exposure of Tenon's capsule fibroblasts of pterygium to cyclosporin 0.05%].
Аннотация на английскомСтатьяРандомизированное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Hercules Laura Almeida, Viveiros Magda Massae Hata, Schellini Silvana Artioli, Candeias João, Padovani Carlos Roberto
Аннотация
PURPOSE: To evaluate normal Tenon capsule fibroblasts and from pterygia in culture when exposed to cyclosporin 0.05%.
METHODS: A prospective, randomized study was done, involving 20 patients with primary pterygium. Samples of normal and pterygium Tenon's capsule from the same individual were collected, cultured and exposed to cyclosporin 0.05%.
RESULTS: Only 7 samples could be exposed to cyclosporin--6 from pterygial Tenon's capsule and 1 from normal Tenon's capsule. There was a significant reduction of cellular proliferation in the cyclosporin exposed cultures (p<0.05).
CONCLUSION: Cyclosporin 0.05% is effective to inhibit the proliferation of pterygia and normal Tenon's capsule fibroblasts. Further studies should be performed to define the role of cyclosporin in pterygium treatment.
METHODS: A prospective, randomized study was done, involving 20 patients with primary pterygium. Samples of normal and pterygium Tenon's capsule from the same individual were collected, cultured and exposed to cyclosporin 0.05%.
RESULTS: Only 7 samples could be exposed to cyclosporin--6 from pterygial Tenon's capsule and 1 from normal Tenon's capsule. There was a significant reduction of cellular proliferation in the cyclosporin exposed cultures (p<0.05).
CONCLUSION: Cyclosporin 0.05% is effective to inhibit the proliferation of pterygia and normal Tenon's capsule fibroblasts. Further studies should be performed to define the role of cyclosporin in pterygium treatment.